Toward a Prefrontal Microcircuit Model for Cognitive Deficits in Schizophrenia

X.-J. Wang

doi:10.1055/s-2006-931501

Pharmacopsychiatry, Table of Contents

Pharmacopsychiatry 2006; 39: 80-87
DOI: 10.1055/s-2006-931501

Original Paper

Toward a Prefrontal Microcircuit Model for Cognitive Deficits in Schizophrenia

X.-J. Wang¹

¹Volen Center for Complex Systems, Brandeis University, Waltham, USA

Abstract

I present here a biophysically-based model of cortical microcircuits capable of both internal representation (memory storage) and dynamical processing (decision and action selection). The model is illustrated through computer simulations that account for neurophysiological and behavioral data from studies using nonhuman primates. This computational theory proposes that an interplay between slow reverberating excitation and competitive synaptic inhibition enables a cortical area, such as the prefrontal cortex, to subserve cognitive functions. It is argued that quantitatively accurate microcircuit models can potentially provide a framework for a systematic approach to pharmacological treatment of schizophrenia and other mental disorders.

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Xiao-Jing Wang

Volen Center for Complex Systems, MS 013, Brandeis University

415 South Street

Waltham, MA 02254-9110

USA

Phone: (781) 736 3147

Fax: (781) 736 2915

Email: xjwang@brandeis.edu